Method for selective inactivation of viral replication

Details Method for selective inactivation of viral replication Method for selective inactivation of viral replication

1997-09-08

2000-12-05

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 71, 435455, 435325, 514 44, 536 231, 536 245, C12Q 168, C12Q 170, C07H 2104

Patent

active

061564966

ABSTRACT:
Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determining whether any interaction of the agent with the component reduces the level of translation of an RNA of the virus.

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Gura, Science, vol. 270, pp. 575-577, Oct. 27, 1995.
Nature Biotechnology, vol. 15, pp. 519-524, Jun. 1997.
Branch, TIBS, vol. 23, pp. 45-50, Feb. 1998.
Pestova et al., J. Virol., vol. 65, No. 11, pp. 6194-6204, Nov. 1991.
Borovjagin et al., Nucleic Acids Res., vol. 19, No. 18, pp. 4999-5005, 1991 .

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