Sulfur-containing HMG-COA reductase inhibitors

Details Sulfur-containing HMG-COA reductase inhibitors Sulfur-containing HMG-COA reductase inhibitors

1992-01-07

1993-10-26

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514570, 546223, 5483235, 548547, 560 11, 560 15, 562426, 562429, A01N 3710, C07C31700

Patent

active

052566927

ABSTRACT:
Novel sulfur-containing compounds which inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, having a sulfur-containing side-chain bonded to a hydrophobic anchor group through an acetylenic or ethylenic linkage. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atheroschlerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.

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patent: 5089523 (1992-02-01), Varma et al.
patent: 5091378 (1992-02-01), Karanewsky et al.
patent: 5099035 (1992-03-01), Saunders et al.

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