Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1991-03-06
1992-12-08
Marquis, Melvyn I.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
525431, 525424, 525446, 525440, 528 28, 528 26, A61K 914
Patent
active
051696410
ABSTRACT:
Polyester/silicon co-crosslinked polymer substrates at least partially degradable by hydrolysis, well adopted as matrices for the controlled release of a wide variety of active agents therefrom, are prepared by controlledly co-crosslinking (a) at least one diorganopolysiloxane having at least two hydroxyl groups per molecule and (b) an oligomeric polylactic and/or polyglycolic polyester .alpha.,.omega.-diol, with an effective co-crosslinking amount of (c) an organic polyisocyanate.
REFERENCES:
patent: 4011312 (1977-03-01), Reuter et al.
patent: 4472465 (1984-09-01), Burrill
patent: 4588770 (1986-05-01), Wurminghausen et al.
patent: 4613641 (1986-09-01), Haubennestel et al.
patent: 4618657 (1986-10-01), Katchko et al.
patent: 4804691 (1989-02-01), English et al.
patent: 4826946 (1989-05-01), Eichenauer et al.
patent: 4927895 (1990-05-01), Nakane et al.
Chemical Abstracts, vol. 68, No. 24, 1968, p. 10229, Resume No. 105798y, Columbus, Ohio, US; & JP-A-43 2949 (Daicell Co. Ltd.) Feb. 2, 1968.
Jorda Rafael
Porte Hugues
Torres Ghislaine
Hellender Karen A.
Marquis Melvyn I.
Rhone-Poulenc Chimie
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