Immunotherapeutic nitriles

Details Immunotherapeutic nitriles Immunotherapeutic nitriles

1995-08-29

1998-03-17

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548472, 548479, 546142, 514417, 514416, 514309, C07D20948, C07D20946, C07D21724, A61K 3140

Patent

active

057288453

ABSTRACT:
Novel nitriles are inhibitors of tumor necrosis factor .alpha. and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3-Phthalimido-3-(3,4-dimethoxyphenyl)propionitrile.

REFERENCES:
patent: 5512682 (1996-04-01), Hilpert
David Cavalla, et al., "Phosphodiesterase IV Inhibitors: Structural Diversity and Therapeutic Potential In Asthma", Current Medical Chemistry, 1995, 2, pp. 561-572.
Louis J. Lombardo, "Phosphodiesterase-IV Inhibitors: Novel Therapeutics for the Treatment of Inflammatory Diseases", Current Pharmaceutical Design, 1995, pp. 255-268.
John A. Lowe, III, et al., "The PDE IV family of calcium-independent phosphodiesterase enzymes", Drugs of the Future, 1992, 17(9): 799-807.
Malcolm N. Palfreyman, "Phosphodiesterase type IV inhibitors as antiinflammatory agents", Drugs of the Future, 1995, 20(8): 793-804.
Les Sekut, et al., "Pathophysiology and Regulation of TNF-.alpha. in Inflammation", DN&P, 9(5), Jun. 1996, pp. 261-269.

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