Process for the production of optically active 2-hydroxy-4-pheny

Details Process for the production of optically active 2-hydroxy-4-pheny Process for the production of optically active 2-hydroxy-4-pheny

1992-07-17

1993-10-26

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435141, 435280, 435822, 435824, 435830, 435836, 435852, 435854, 435856, 435857, 435853, 435873, 435874, 435885, 435911, 435921, 435930, C12P 742, C12P 4100, C12R 1465, C12R 1245

Patent

active

052565521

ABSTRACT:
2-Oxo-4-phenylbutyric acid is treated with a microorganism, which has been optionally treated, capable of asymmetrically reducing 2-oxo-4-phenylbutyric acid into either (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid, and the (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid thus produced is recovered to thereby give optically active 2-hydroxy-4-phenylbutyric acid.
The optically active 2-hydroxy-4-phenylbutyric acid is an important intermediate in the synthesis of various drugs such as a remedy for hypertension.

REFERENCES:
patent: 4530903 (1985-07-01), Leuchtenberger et al.
patent: 4609623 (1986-09-01), Leuchtenberger et al,
patent: 4824781 (1989-04-01), Hummel et al.
Biotech Abs. 85-12678 J601565394 Aug. 1985.
Biotech Abs 90-05694 J02016987 Jan. 1990.
Biotech Abs 89-14981 WO8907147 Aug. 1989.
Biotech Abs. 90-03378 EP-347374 Dec. 1989.
Biquard, Ann. de Chim., 20, 146 (1933).

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