Coating processes – Fraud or tamper detecting
Patent
1992-06-22
1993-10-26
Owens, Terry J.
Coating processes
Fraud or tamper detecting
427275, 427467, 427480, A61K 944, B05D 300
Patent
active
052564401
ABSTRACT:
Process for preparing and film coating a dosage form. An intagliated dosage form core is produced by inscribing one or more areas on the surface of the dosage form core prior to coating. An aqueous dispersion of a polymeric coating is then applied to the intagliated dosage form core. When placed in an environment of use, the film coating within the circumscribed region of the dosage form surface is reproducibly expelled, leaving a coated core tablet with a predefined aperture in the coating which exposes a discrete portion of the core surface to the environment of use.
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Appel Leah E.
Zentner Gaylen M.
Bigley Francis P.
Cameron Erma
DiPrima Joseph F.
Merck & Co. , Inc.
Owens Terry J.
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