Composition for determining viability of tissue

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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Details

514261, 514262, 514263, 514264, 514266, A61K 3152

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active

052563987

ABSTRACT:
A method and composition of determining the viability of tissue in a region of an organism having a vascular circulatory system that supplies blood to said region is disclosed. The composition includes the combination of adenosine or an adenosine antagonist in combination with an A.sub.1 adenosine receptor which may be: ##STR1## wherein R.sub.1 is hydrogen or R.sub.2 ; R.sub.2 is selected from the group consisting of endo-2-norbornyl or cyclopentyl; R.sub.3 is selected from the group consisting of hydrogen, halogen, amine, carboxy, alkyl radicals having 1 to 10 carbon atoms, cycloalkyl radicals having from 3 to 8 ring carbon atoms, thio sulfonate, sulfonamide, sulfone, sulfoxamide, phenyl, alkyl-substituted amine, and cycloalkyl substituted amine; R.sub.4 is selected from the group consisting of benzyl, phenyl, alkyl groups comprising from 1 to 4 carbon atoms, wherein said alkyl group can be substituted with oxygen, for instance ethers and alcohols; and R.sub.5 is selected from the group consisting of hydrogen, hydroxy, sulfonate, halogen, alkoxy and cycloalkoxy groups comprising 1 to 6 carbon atoms.

REFERENCES:
patent: 4696932 (1989-09-01), Jacobson et al.
patent: 4769377 (1988-09-01), Snyder et al.
patent: 4788500 (1988-11-01), Patz et al.
patent: 4803977 (1989-02-01), Kremer, Jr.
patent: 4824660 (1989-04-01), Angello et al.
patent: 4855300 (1989-08-01), Nandi et al.
patent: 4904472 (1990-02-01), Belardinelli et al.
patent: 5070877 (1991-12-01), Mohiuddin et al.
T. Rall in "The Pharmacological Bosis of Therapeutics", A. Goodman et al. eds., 6th ed., pp. 592-604, Macmillian Publishing Co., New York (1980).
"Hackh's Chemical Dictionary", J. Grant ed., 4th ed., p. 646, McGraw-Hill Book Co., New York (1969).
Texas Cardiovascular Imaging Center memo dated Jan. 4, 1989.
Jacobsen e al., Biochemical Pharmacology, 41(10) 1399-1410 (1991).
Pelleg et al., Pharmacotherapy, 10(3) 157-174 (1990).
Williams et al., Current Cardiovascular Patents, 1, 560-576 (1989).

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