Structural gene of pneumococcal protein

Details Structural gene of pneumococcal protein Structural gene of pneumococcal protein

1994-03-17

1998-03-17

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

530350, 4242441, A61K 3902, A61K 3909, C07K 100, C07K 1400

Patent

active

057283877

ABSTRACT:
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

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