Methods and compositions incorporating IP-10

Drug – bio-affecting and body treating compositions – Lymphokine

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 695, 530351, A61K 4505

Patent

active

057283770

ABSTRACT:
The present invention discloses the correct processing of IP-10, a myelosuppressive protein produced by certain cells such as keratinocytes, monocytes and human endothelial cells upon stimulation by .gamma.-interferon. Also disclosed is a method of treating human cancer patients by applying IP-10 in a pharmaceutical composition in conjunction with certain antineoplastic agents.

REFERENCES:
Chen et al., "Carbohydrate Variant of the Recombinant .beta.-Subunit of Human Choriogonadotropin Expressed in Baculovirus Expression System," The Journal of Biological Chemistry, 266(7):4081-4087, 1991.
Chen and Bahl, "Recombinant Carbohydrate Variant of Human Choriogonadotropin .beta.-Subunit (hCG.beta.) Descarboxyl Terminus (115-145)," The Journal of Biological Chemistry, 266(10):6246-6251, 1991.
Chiou and Wu, "Expression of Human Granulocyte-Macrophage Colony-Stimulating Factor Gene in Insect Cells by a Baculovirus Vector," FEBS Letters, 259(2):249-253, 1990.
Chua and Blomberg, "Immunochemical Studies of Thylakoid Membrane Polypeptides for Spinach and Chlamydomonas reinhardtii," The Journal of Biological Chemistry, 254:215-223, 1979.
Davidson and Castellino, "Asparagine-Linked Oligosaccharide Processing in Lepidopteran Insect Cells. Temporal Dependence of the Nature of the Oligosaccharides Assembled on Asparagine-289 of Recombinant Human Plasminogen Produced in Baculovirus Vector Infected Spodoptera frugiperda (IPLB-SF-21AE) Cells," Biochemistry, 30:6165-6174, 1991.
Dimitriadis, "Effect of Detergents on Antibody-Antigen Interaction," Analytical Biochemistry, 98:445-451, 1979.
Gillespie et al., "Expression of Biologically Active Human Antithrombin III by Recombinant Baculovirus in Spodoptera frugiperda Cells," The Journal of Biological Chemistry, 266(6):3995-4001, 1991.
Ingley et al., "Production and Purfication of Recombinant Human Interleukin-5 from Yeast and Baculovirus Expression Systems," Eur. J. Biochem., 196:623-629, 1991.
Jarvis and Summers, "Glycosylation and Secretion of Human Tissue Plasminogen Activator in Recombinant Baculovirus-Infected Insect Cells," Molecular and Cellular Biology, 9(1):214-223, 1989.
Lebacq-Verheyden et al., "Posttranslational Processing of Endogenous and of Baculovirus-Expressed Human Gastrin-Releasing Peptide Precursor," Molecular and Cellular Biology, 8(9):3129-3135, 1988.
Luckow and Summers, "High Level Expression of Nonfused Foreign Genes with Autographa californica Nuclear Polyhedrosis Virus Expression Vectors," Virology, 170:31-39, 1989.
Luster et al., ".gamma.-Interferon Transcriptionally Regulates an Early-Response Gene Containing Homology to Platelet Proteins," Nature, 315(6021):672-676, 1985.
Miyajima et al., "Use of the Silkworm, Bombyx mori, and an Insect Baculovirus Vector for High-Level Expression and Secretion of Biologically Active Mouse Interleukin-3," Gene, 58:273-281, 1987.
Nakhai et al., "The .alpha. Subunith of Human Chorionic Gonadotropin Hormone Synthesized in Insect Cells using a Baculovirus Vector is Biologically Active," FEBS Letters, 283(1):104-108, 1991.
Quelle et al., "High-Level Expression and Purification of a Recombinant Human Erythropoietin Produced Using a Baculovirus Vector," Blood, 74(2):652-657, 1989.
Rodewald et al., "Production of Murine Interleukin-4 and Interleukin-5 by Recombinant Baculovirus," Journal of Immunological Methods, 132:221-226, 1990.
Sarris et al., "Recombinant Human IP-10: Expression, Biochemical Characterization, Purification and Inhibition of Early Human Hematopoietic Progenitors," ISEH, 1993, Abstract only.
Smith et al., "Production of Human Beta Interferon in Insect Cells Infected with a Baculovirus Expression Vector," Molecular and Cellular Biology, 3(12):2156-2165, 1983.
Smith et al., "Modification and Secretion of Human Interleukin 2 Produced in Insect Cells by a Baculovirus Expression Vector," Proc. Natl. Acad. Sci. USA, 82:8404-8408, 1985.
Steiner et al., "Human Tissue-Type Plasminogen Activator Synthesized by Using a Baculovirus Vector in Insect Cells Compared with Human Plasminogen Activator Produced in Mouse Cells," Gene, 73:449-457, 1988.
Whitefleet-Smith et al., "Expression of Human Plasminogen cDNA in a Baculovirus Vector-Infected Insect Cell System," Archives of Biochemistry and Biophysics, 271(2):390-399, 1989.
Wojchowski et al., "Active Human Erythropoietin Expressed in Insect Cells Using a Baculovirus Vector: A Role for N-Linked Oligosaccharide," Biochimica et Biophysica Acta, 910:224-243, 1987.
Dewald et al., "IP-10, a .gamma.-Interferon-inducible Protein Related to Interleukin-8, Lacks Neutrophil Activating Properties," Immunology Letters, 32:81-84, 1992.
Luster and Leder, "IP-10, a -C-X-C Chemokine, Elicits a Potent Thymus-dependent Antitumor Response In Vivo," J. Exp. Med., 178:1057-1065, 1993.
Narumi et al., "Tissue-specific Expression of Murine IP-10 mRNA Following Systemic Treatment with Interferon .gamma.," Journal of Leukocyte Biology, 52(1):27-33, 1992.
Ohmori and Hamilton, "A Macrophage LPS-Inducible Early Gene Encodes the Murine Homologue of IP-10," Biochemical and Biophysical Research Communications, 168(3):1261-1267, 1990.
Smoller and Krueger, "Detection of Cytokine-induced Protein .gamma.-Immune Protein-10 (.gamma.-IP10) in Atypical Melanocytic Proliferations," 25(4):627-631, 1991.
Broxmeyer, et al "Synergistic Suppressive Interactions of Human Chemokines on Human Myeloid Progenitor Cell Proliferation", Molecular Biology of Hematopoiesis 8th Symposium, Basel, Switzerland, Jul. 9-13, 1993, Abstract only.
Broxmeyer et al J of Immun. 150(8): 3448-4458 (Apr. 15, 1993).
Luster et al J of Exp Med. 166: 1084-1097, 1987.
Oppenheim The Chemokines, 1993, pp. 183-186.
Luster et al J of Ex Med 166: 1098-1108, 1987.
Luster et al, Keystone Symposia Jan./Feb. 1993, p. 121.
Harlow et al In Antibiotics, A Lab. Manual, Cold Spring Harbor Lab. 1988, pp. 285 and 287.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and compositions incorporating IP-10 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions incorporating IP-10, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions incorporating IP-10 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-955286

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.