Polyether nucleic acids

Details Polyether nucleic acids Polyether nucleic acids

1996-10-30

1999-06-01

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 44, 514269, 514885, 514908, 536 253, 536 2531, 536 2532, 536 254, 536 43, 536 44, 536 231, 544242, 544264, 435 6, A61K 31075, C07D23900, C07D47300

Patent

active

059088451

ABSTRACT:
A compound comprising a polyether backbone bearing a plurality of ligands that are individually bound to chiral carbon atoms located within said backbone, at least one of said ligands including a moiety selected from the group consisting of a naturally occurring nucleobase, a nucleobase binding group and a DNA intercalator; a process of synthesizing the compound, monomers to be used in this process and their synthesis process and processes for using the compound in biochemistry and medicine.

REFERENCES:
patent: 5519134 (1996-05-01), Acevedo et al.
patent: 5608046 (1997-03-01), Cook et al.
patent: 5637684 (1997-06-01), Cook et al.
patent: 5688941 (1997-11-01), Cook et al.
patent: 5717083 (1998-02-01), Cook et al.
Burch et al, "Oligonucleotides Antisense to the Interlukin 1 Receptor mRNA Block the Effects of Interlukin 1 in Cultures Murine and Human Fibroblasts and in Mice", J. Clin. Inv., vol. 88, pp. 1190-1196, (1991).
Calabretta et al, "Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense ologideoxynucleotides: An in vitro study relevant to bone marrow purging", Proc. Natl. Acad. Sci. USA, vol. 88, pp. 2351-2355, (1991).
Dash et sl, "Selective elimination of mRNAs in vivo: Compementary ologideoxynucleotides promote RNA degradation by an Rnase H-like activity", Proc. Natl. Acad. Sci. USA, vol. 84, pp. 7896-7900, (1987).
Heikkila et al, "A c-myb antisense ologideoxynucleotide inhibits entry into S phase but not progress from G.sub.0 to G.sub.1 ", Nature, vol. 328, 445-449, (1987).
Nielson et al, "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science, vol. 254, pp. 1497-1500, (1991).
Paterson et al, "Structural gene identification and mapping by DNA.cndot.mRNA hybrid-arrested cell-free translation", Proc. Natl. Acad. Sci. USA, vol. 74, No. 10, pp. 4370-4374, (1977).
Reed et al, "Antosense-mediated Inhibition of BCL2 Protooncogeene Expression and Leukemic Cell Growth and Survival: Comparisons of Phosphodester and Phosphorothioate Ologideoxynucleotides", Cancer Research, vol. 50, pp. 6565-6570, (1990).
Szczylik et al, "Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Ologideoxynucleotides", Science, vol. 253, pp. 562-565, (1991).
Uhlmann et al, "Antisense Ologideoxynucleotides: A New Therepeutic Principle", Chem. Rev., vol. 90, No. 4, pp. 544-584, (1990).
Flam, F., "Can DNA Mimics Improve on the Real Thing?", Science, vol. 262, pp. 1647-1648, (1993).
Thuong et al, "Sequence-Specific Recognition and Modification of Double-helical DNA by Ologideoxynucleotides", Angew. Chem. Int. Engl., vol. 32, pp. 666-690, (1993).
Zalipsky, S., "Functionalized Poly(ethylene glycol) for Preparation of Biologically Relevant Conjugates," Bioconjugate Chem., vol. 6, pp. 150-165, (1995).
Cohen, J., "Ologideoxynucleotide therepeutics", Trends in Biotechnology, vol. 10, No. 3, pp. 87-91, (1992).
Delgado, C., "The Uses and Properties of PEG-Linked Proteins", Critical Reviews in Therepeutic Drug Carrier Systems, vol. 9, pp. 249-304, (1992).
Augustyns et al, "Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl) adenine on the enzymatic stability and base-pairing properties of ologideoxynucleotides", Nucleic Acids Research, vol. 19, No. 10, pp. 2587-2593, (1991).
Buchardt et al, "Peptide nucleic acids and their potential applications in biotechnology", Tibtech, vol. 11, pp. 384-386, (1993).
Agrawal, S., "Antisense ologideoxynucleotides as antiviral agents", Tibtech, vol. 10, No. 5, pp. 152-158, (1992).
Wahlestedt, C., "Antisense ologideoxynucleotide strategies in neuropharmacology", TIPS, vol. 15, pp. 42-46, (1994).
Cook, P.D., "Medicinal chemistry of antisense ologideoxynucleotides -- future opportunities", Anti-Cancer Drug design, vol. 6, pp. 585-607, (1991).
Green, et al, "The Role of Antisense RNA in Gene regulation", Ann. Rev. Biochem., vol. 55, pp. 569-597, (1986).

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