Histone-like protein

Details Histone-like protein Histone-like protein

1998-06-18

1999-06-01

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 691, 4352523, 4353201, 530350, 536 231, 536 235, A61K 3800, C12P 2106, C12N 120, C07H 2104

Patent

active

059088311

ABSTRACT:
The present invention provides a human histone-like protein (HLP) and polynucleotides which identify and encode HLP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTP and for treating disorders associated with the expression of HLP.

REFERENCES:
Rabbani et al. (1992). Biochem. Biophys. Acta 1171:229-230.
Kohnke-Godt, B. et al., "Heparin-Binding Lectin from Human Placenta: Further Characterization of Ligand Binding and Structural Properties and Its Relationship to Histones and Heparin-Binding Growth Factors", Biochemistry, 30: 55-65 (1991).
Rabbani, S.A. et al., "Nucleotide and (derived) amino acid sequence of a novel peptide from a rat (hypercalcemic) Leydig cell tumor", Biochim. Biophys. Acta, 1171: 229-230 (1992).
Rabbani, S.A. et al., (Direct Submission), GenBank Sequence Database (Accession 57064), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 57064).
Dobner. T. et al., "A novel divergently transcribed human histone H2A/H2B gene pair", DNA Sequence, 1: 409-413 (1991) (GI 1082448).

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