Pharmaceutical compositions of conjugated estrogens and methods

Details Pharmaceutical compositions of conjugated estrogens and methods Pharmaceutical compositions of conjugated estrogens and methods

1996-07-25

1999-06-01

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424468, 424470, 424472, 424474, 424480, 424482, 514960, A61K 936, A61K 3156

Patent

active

059086386

ABSTRACT:
This invention relates to novel pharmaceutical compositions and methods for their preparation containing conjugated estrogens for the treatment of peri-menopausal, menopausal and post-menopausal disorders in women. The novel pharmaceutical compositions comprise a carrier base material and conjugated estrogens formed into a solid unit dosage form possessing a regular incremental release of the medicament upon oral administration. Further, the invention comprises the combination of conjugated estrogens with progestogens in a solid, shaped dosage unit. Specifically, the invention comprises the use of an organic excipient such as high molecular weight hydroxyalkyl alkylcelluloses. The use of an organic excipient such as hydroxypropylmethylcellulose in a stable, solid dosage formulation containing either conjugated estrogens alone or in combination with a progestogen is described.

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Havlik and Feinleib (1979) Dept. HEW NIH Pub. No. 79-1610.
Conjugated Estrogens, USP23-NF18, 627-628 (1995).
Conjugated Estrogens, USP23-NF18 Supp. 2, 2631-2632 (1995).

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