Process for the production of calcium salts of hydantoic acids

Details Process for the production of calcium salts of hydantoic acids Process for the production of calcium salts of hydantoic acids

1993-02-12

1994-08-16

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483144, 5483171, 548492, 548532, 562443, 562446, 562539, 562560, 562561, 546227, C07D23390, C07D21160, C07D20716, C07C149247

Patent

active

053388593

ABSTRACT:
The present invention provides a process for the production of calcium salts of hydantoic acids and which comprises the steps of reacting a hydantoin with a calcium base material such as calcium hydroxide in an aqueous medium at a sufficient temperature and for a sufficient period of time to form the calcium salt of the corresponding hydantoic acid and then separating the calcium salt of such acid from the reaction mass. This separation can include the further steps of cooling the reaction mass down to facilitate the precipitation of the acid/salt crystals and then separating the precipitate by means of filtering or centrifugating. These acids can then be subjected to a HNO.sub.2 -mediated decarbamoylation process followed by an optical resolution step to thus provide high yields of D-p-hydroxyphenylglycine which is a key synthetic immediate or building block for semi-synthetic penicillin and cephalosporins.

REFERENCES:
patent: 2557920 (1951-06-01), White
patent: 3668221 (1972-06-01), Shima et al.
patent: 3790599 (1974-02-01), Zundel
patent: 3833651 (1974-09-01), Ouchi et al.
patent: 3917683 (1975-11-01), Ouchi et al.
patent: 4069251 (1978-01-01), Mannsfeld et al.
patent: 4272631 (1981-06-01), Schaaf et al.
patent: 4391988 (1983-07-01), Spindler et al.
patent: 4436910 (1984-03-01), Kleemann et al.
patent: 4518801 (1985-05-01), Bolze et al.

Affiliated with

Also associated with

Rating

Process for the production of calcium salts of hydantoic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of calcium salts of hydantoic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of calcium salts of hydantoic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-953143