Production of bordetella pertussis toxin with a low concentratio

Details Production of bordetella pertussis toxin with a low concentratio Production of bordetella pertussis toxin with a low concentratio

1992-12-11

1994-08-16

Knode, Marian

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

4352521, 435244, 435246, 435822, C12P 2100

Patent

active

053386701

ABSTRACT:
A fermentation level cultivation of Bordetella pertussis bacteria on commercial scale is described. The critical factors in large scale cultivation of the bacteria are the presence of an antifoam agent and maintaining proper oxygen level and iron content in the culture medium. Pertussis toxin produced by the bacteria parallels the rate of growth of the bacteria.

REFERENCES:
patent: 2822319 (1954-08-01), Monod
patent: 4687738 (1987-08-01), Ginnaga et al.
Staimer, D. W. et al., "A Simple Chemically Defined Medium for the Production of Phase I" Bordatella Petrussis, J. General Microbiology, 63:211-220, 1971.
Armstrong, S. K. et al., "Effects of Iron Starvation on Bordatella Petrussis", Abstracts of the Annual Meeting of The American Society for Microbiology, Mar. 4-9, 1984.
Sekura, et al., (1983), J. Biol. Chem., 258:23, pp. 14647-14651, "Pertussis Toxin, Affinity Purification of a new ADP-Ribosyltransferase".
Sekura, et al., (1985), Methods of Enzymology, 109, p. 556 -"ADP-Ribosylation of Membrane Components by Pertussis and Cholera Toxin".

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