Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1992-01-13
1994-08-16
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 74, 435 19, 435 23, 435219, C12Q 100, C12Q 144, C12Q 137, C12N 950
Patent
active
053386639
ABSTRACT:
Disclosed is a method for identifying a compound which inhibits the esterase activity of .beta.-protein. More specifically, in the method disclosed, .beta.-protein is combined with an appropriate substrate and a compound to be tested for its ability to inhibit the enzymatic activity of .beta.-protein (candidate inhibitor). Failure of .beta.-protein to act upon the substrate is an indication that the candidate inhibitor is, in fact, effective as an inhibitor of the .beta.-protein activity. Specifically, the extent to which .beta.-protein acts upon the substrate is determined and compared with the extent to which .beta.-protein acts upon the substrate in the absence of the candidate inhibitor.
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Kayyali Usamah
Potter Huntington
Gitomer Ralph
President and Fellows of Harvard College
Wityshyn Michael G.
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