Tricyclic isoindole derivatives

Details Tricyclic isoindole derivatives Tricyclic isoindole derivatives

1981-02-19

1983-12-27

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548431, C07D20946

Patent

active

044232322

ABSTRACT:
Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino]2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.
Claimed compounds include those of the formula ##STR1## in which R.sup.3 and R.sup.4 each is hydrogen, lower alkoxy, lower alkyl, trifluoromethyl, halo or hydroxy, or R.sup.3 and R.sup.4 together form an OCH.sub.2 O chain; and R.sup.14 and R.sup.15 each is hydrogen or lower alkyl.

REFERENCES:
patent: 3892771 (1975-07-01), Eberle
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Derwent Publications Ltd., Farmdoc 21903v for Japanese Patent J4 9014459.
Chem. Abst. 78:58179s (1973) for Tetra. Letters, 4517 (1972).
Chem. Abst. 55:15485c (1961) for Gazz Chim. Ital., 90, 559 (1960).
E. Breuer et al., Tetrahedron, 31, 499 (1975).
F. M. Rowe et al., J. Chem. Soc., 1098 (1936).
Chem. Abst. 94:47112u (1981).

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