Nucleic acid encoding adhesion variants

Details Nucleic acid encoding adhesion variants Nucleic acid encoding adhesion variants

1995-06-01

2000-09-12

Mertz, Prema

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 231, 536 234, 536 235, 536 2353, 435 711, 435 712, 435325, 4352523, 43525411, 4353201, 435471, C12N 1513, C12N 1562, C12N 1563

Patent

active

061176559

ABSTRACT:
Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.

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