Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1988-03-15
1991-02-05
Kepplinger, Esther M.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 858, 436548, 530387, 530808, 530809, 435 721, 4351722, 43524027, 435 732, 935103, 935107, 935110, G01N 3348, G01N 3353, G01N 5300, C12N 1500
Patent
active
049903268
ABSTRACT:
Use of labeled monoclonal antibody 50 H.19 to detect the location and concentration of blood platelets in a host is disclosed. MAb 50 H.19 labeled with a label which can be detected from without the host (e.g. a radiolabel or NMR-label) is intravenously injected to immunoreact with platelets in vivo or is first immunoreacted in vitro with platelets, which are then intravenously injected into the host. By means of the labeled MAb 50 H.19 bound platelets it is possible to detect and locate thrombi, emboli, atherosclerotic obstructions, bacterial endocarditis and to do spleen imaging. In another embodiment of the invention, the MAb 50 H.19 is bound to an enzymatic thrombolytic agent and injected intravenously to permit the therapeutic application of the agent directly to thrombi.
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Oster et al., Thrombus Radioimmunoscintigraphy: An Approach Using Monoclonal Antiplatelet Antibody, PNAS, 82, 3465-3468, May 1985.
Longenecker Bryan M.
Noujaim Antoine A.
Graeter Janelle
Kepplinger Esther M.
Summa Medical Corporation
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