Glycine receptor antagonist pharmacophore

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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540491, 540507, 540523, 544 1, 544 94, 544105, 544234, 544285, 544344, 544355, 546 13, 546153, 546157, 546158, 5483064, 548483, 548485, 548486, 548492, 562455, 564 44, 564441, 564442, C07D24144, C07D26536, A61K 31495, A61K 31535

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055979220

ABSTRACT:
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions and inducing anesthesia are disclosed by administering to an animal in need of such treatment a compound which has high binding to the glycine receptor.

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