NF-.kappa.B activation regulatory protein, I.kappa.B-.beta.

Details NF-.kappa.B activation regulatory protein, I.kappa.B-.beta. NF-.kappa.B activation regulatory protein, I.kappa.B-.beta.

1995-02-15

1997-01-28

Fleisher, Mindy

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1447

Patent

active

055978983

ABSTRACT:
The present invention provides a novel polypeptide, I.kappa.B-.beta., which binds to and affects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-.beta. and methods of identifying compositions which affect I.kappa.B-.beta..backslash.NF-.kappa.B complexes. Methods of treatment of disorders associated with NF-.kappa.B induced gene activation are also described herein.

REFERENCES:
Kerr, et al., The Rel-associated pp. 40 protein prevents DNA binding of Rel and Nf.kappa.B: relationship with I.kappa.B.beta. and regulaton by phosphorylation; Genes & Development, 5:1464-1476, 1991.
Purified Human I.kappa.B Can Rapidly Dissociate the Complex of the NF.kappa.B Transcription Factor with its Cognate DNA Zabel and Baeuerle, Cell 61:255-265, Apr. 20, 1990.
Activation in vitro of Nf.kappa.B by phosphorylation of its inhibitor I.kappa.B Ghosh and Baltimore, Nature, vol. 344:678-682, Apr. 1990.
Purified I.kappa.B-.beta. Is Inactivated upon Dephosphorylation Link, et al., The Jrnl. of Bio. Chem., 267:239-246, Jan. 5, 1992.

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