Combination chemotherapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514553, 514597, A61K 3144

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active

055978304

ABSTRACT:
Suramin in combination with a vinca alkaloid or estramustine is synergistic for treating cancer.

REFERENCES:
patent: 5158940 (1992-10-01), LaRocca et al.
Carter et al., Chemotherapy of Cancer, 2nd Ed, 1981, Johy Wiley & Sons, N.Y., N.Y., pp. 82-85.
PCT International Search Report, PCT/US 95/14008.
Proceedings of the American Association for Cancer Research, vol. 35, 1994, Rago et al., p. 329, abstract 1956.
Molecular Pharmacology, vol. 33, No. 4, 1988, Zamora et al., pp. 454-462.
Studies of Suramin (Antrypol: Bayer 205), vol. 40, 1946, Dewey et al., pp. 119-124.
Journal of Clinical Oncology, vol. 7, No. 4, 1989, Stein et al., pp. 499-508.
Journal of the National Cancer Institute, vol. 86, No. 20, 1994, Chou et al., pp. 1517-1524.
Synergism and Antagonism in Chemotherapy, Chapter 6, 1991, Chou et al., pp. 223-241.
Journal of the National Cancer Institute, vol. 82, No. 14, 1990, Fruehauf et al., pp. 1206-1209.

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