Treatment with lys-plasminogen of reperfusion injury and brain e

Details Treatment with lys-plasminogen of reperfusion injury and brain e Treatment with lys-plasminogen of reperfusion injury and brain e

1994-11-21

1997-01-28

Naff, David M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 9464, 514802, A61K 3848, A61K 3800

Patent

active

055978002

ABSTRACT:
A treatment of ischemia and the attendant reperfusion injury entails the administration plasmin and plasmin-forming proteins, including lys-plasminogen and similar substances. Lys-plasminogen, which can be obtained from the proteolytic cleavage of glu-plasminogen, has been found to have a protective effect on tissue that has been injured by ischemic conditions. The administration of lys-plasminogen alone, in a dosage of about 10-1000 caseinolytic units/kg, can be used to treat subjects during the time of reperfusion and after reperfusion has already occurred. Lys-plasminogen also can be administered in conjunction with clot lysis therapies, such as those that employ tissue plasminogen activator and the like. Lys-plasminogen can also lessen cerebral edema which results from cerebral ischemia.

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