Cloning of a malarial gene

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 4352523, 4352542, 435363, 435325, 43525233, 536 231, 536 234, 536 237, C12N 1530, C12N 1562, C12N 121, C12P 2102

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055977081

ABSTRACT:
The present invention relates to the P.195 gene of Plasmodium falciparum and, more specifically, to the cloning of that gene. The invention further relates to a method of producing the P.195 protein using the cloned gene. The invention also relates to a vaccine comprising the P.195 protein and to the use of same in the prophylaxis of malaria.

REFERENCES:
patent: 4466917 (1984-08-01), Nussenzweig
Young et al Proc. Natl. Acad Sci USA vol. 80 pp. 1194-1198 (1983).
Ellis et al. Nature vol. 302 pp. 536-538 (1983).
Watsai in Molecular Biology of The Gene 3rd Edition W. A. Benjamin Inc. Menlo Park CA (1976) p. 702.
Maniatis et al. Molecular Cloning: A Laboratory Manual Cold Spring Harbor Laboratory CSH, NY (1982) pp. 270-274 or 310-319.
Ada in Fundamental Immunology, 2nd Edition edited by W. E. Paul, Raven Press Ltd, NY (1989) pp. 985-1031.
Butcher Parasitology vol. 98 pp. 315-327 (1989).
Cox TibTech vol. 9 pp. 389-394 (1991).
Eisen in Immunology, 2nd Edition, Harper & Row Publishers, Hagerstown PA (1980) pp. 294 & 436-437.
Stedman's Medical Dictionary 25th Edition Williams & Wilkins Baltimore MD (1990) p. 1680.
Phillips et al Parasitology Today vol. 2 pp. 271-282 (1986).
Nussentweig et al Science vol. 265 pp. 1381-1383 (1994).
Crisanti et al Science vol. 240 pp. 1324-1326 (1988).
Odink et al FEBS vol. 173 pp. 108-112 (Jul. 1984).
Holder et al, "Immunization against Plasmodium falciparum with recombinant polypeptides produced in Escherichia coli", Parasite Immunology 10:607-617 (1988).
Certa et al, "Aldolase Activity of a Plasmodium falciparum Protein with Protective Properties", Science 240:1036-1038 (1988).
Thaithong et al, "Clonal diversity in a single isolate of the malaria parasite Plasmodium falciparum", Transactions of the Royal Society of Tropical Medicine and Hygiene, 78:242-245 (1984).
Hall et al, "Major surface antigen genes of a human malaria parasite cloned and expressed in bacteria", Nature 311: (Sep. 1984).
Perrin et al, "Antimalaria Immunity in Saimiri Monkeys", J. Exp. Med. 160:441-451 (1984).
McBride et al, "Serotyping Plasmodium falciparum from acute human infections using monoclonal antibodies", Transactions of the Royal Society of Tropical Medicine and Hygiene 78:32-34 (1984).
"Antigenic Diversity in the Human Malaria Parasite", Science 217:254-257 (1982).
Freeman et al, "Surface Antigens of Malaria Merozoites", J. Exp. Med. 158:1647-1653 (1983).
Holder et al, "The Three Major Antigens on the Surface of Plasmodium Falciparum Meroxoites are Derived from a Single High Molecular Weight Precursor", J. Exp. Med. 160:624-629 (1984).
Hall et al, "Processing Polymorphism and Biological Significance of p190, A Major Surface Antigen of the Erythrocytic Forms of Plasmodium Falciparum", Molecular and Biochemical Par. 11:61-80 (1984).
Holder et al, "Biosynthesis and Processing of a Plasmodium Falciparum Schizont Antigen Recognized by Immune Serum and a Monoclonal Antibody", J. Exp. Med. 156:1528-1538 (1982).
David et al, "Processing of a Major Parasite Surface Glycoprotein During the Ultimate States of Differentiation in Plasmodium Knowlesi", Molecular and Biochem. Par. 11:267-282 (1984).
Epstein et al, "Monoclonal Antibodies Against a Specific Surface Determinant on Malarial (Plasmodium Knowlesi) Merozoites Block Erythrocyte Invasion", J. of Immunology 127(1):212-217 (1981).
Boyle et al, "Monoclonal Antibodies that Protect In Vivo Against Plasmodium Chabaudi Recognize a 250,000-Dalton Parasite Polypeptide", Infection and Immunity 38(1):94-102 (1982).
Holder et al, "Serological Cross-Reaction Between High Molecular Weight Proteins Synthesized in Blood Schizonts of Plasmodium Yoel II, Plasmodium Chabaudi . . . ", Molecular and Biochem Par. 9;191-196 (1983).
Majarian et al, "Passive Immunization Against Murine Malaria with an IgG3 Monoclonal Antibody", J. of Immunology 32(6):3131-3132 (1984).
Freeman et al, "Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii Schizont antigen", Clin. Exp. Immunol. 54:609-616 (1983).
Laemmli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4", Nature 227:680-685 (1970).
Holder et al, "Characterization of a high molecular weight protective antigen of Plasmodium yoelii", Para. 88:211-219 (1984).
Holder et al, "Immunization against blood-stage roden malaria using purified parasite antigens", Nature 294:361-364 (1981).
Odinik et al, Molecular and Biochemical Parasitology, 10:55-66 (1984).
Kemp et al, Proc. Natl. Acad. Sci. USA 30:3787-3791 (1983).
Stites et al, Basic and Clinical Immunology, 5th ed., Lange Medical Publications, Los Allas, CA 1984, p. 698.

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