Prolonged release of biologically active somatotropin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 6, 514 12, 514 21, 530399, A61K 3736, C07K 1300

Patent

active

050137131

ABSTRACT:
Prolonged parenteral release of a bioactive polypeptide at desirably effective levels can be achieved using novel compositions in which the polypeptide is present in a biocompatible oil in an unusually high proportion such as at least about 10% by weight. Also disclosed are certain metal-associated somatotropins that are useful for prolonged parenteral release of such somatotropins.

REFERENCES:
patent: 2491537 (1949-12-01), Welch
patent: 2807569 (1954-01-01), Homan et al.
patent: 3118815 (1964-01-01), Li
patent: 3678027 (1972-07-01), De Jager et al.
patent: 3810881 (1974-05-01), Rittel et al.
patent: 4172138 (1979-10-01), Rhodes
patent: 4256737 (1981-03-01), Nestor et al.
patent: 4328214 (1982-05-01), Rink et al.
patent: 4343789 (1982-08-01), Kawata et al.
patent: 4452775 (1984-06-01), Kent
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4659696 (1987-04-01), Hirai et al.
Davis et al., J. Dairy Science (1983), 66:1980-1982.
Sokol & Sise, "The Effect of Exogenous Vasopressin and Growth Hormone on the Growth of Rats with Hereditary Hypothalamic Diabetes Insipidus", Growth 37:127-142 (1973).
Besser, et al., "Growth Hormone Release Inhibiting Hormone in Acromegaly", Brit. Med. J. 2:352-355 (1974).
Wolfson, et al., "The Development, Evaluation, and Clinical Use of Long-Acting ACTH Preparations", Proc. of the Second Clinical ACTH Conf., J. R. Mote, ed., pp. 1-29 (1951).
W. Wolfson, et al., "An Excellently Tolerated, Heat-Stable, Long Acting ACTH Preparation Suitable for Prolonged & Ambulatory Treatment", Abstracts of Papers of Thirty-Third Meeting: 11, p. 800 (1952).
W. Wolfson, and S. Fajans, "A Comparison of the Duration of Action of Various Long-Acting ACTH Preparations in Human Subjects", New Eng. Jour. Med. 246:1000-1004 (1952).
Bruce, A. Parkes, W. Perry, "Assay of ACTH on the Thymus of The Nestling Rat", Lancet, pp. 790-2793 (1952).
W. Wolfson, "The Three Subtypes of Pituitary Adrenocorticotropin", AMA Archives of Internal Med., pp. 108-147 (ca. 1953).
Thompson and Fisher, "Correlation of ACTH Assays", Endocrinol. 52:496-509, (1953).
Thompson, "Sustained Release of Parenteral Drugs", Bulletin of Parental Drug Assoc., pp. 6-16, (1960).
W. Wolfson, et al., "The Probability the Increased Secretion of Oxysteriods Does Not Fully Explain Improvement in Certain Systemic Diseases During Pregnancy", JMSMS, pp. 1019-1022, (1952).
Buckwalter and Dickison, "The Effect of Vehicle and Particle Size on the Absorption of the Intramuscular Route of Procaine Penicillin G Suspension", J. Amer. Pharm. Assn. XLVII:661-666, (1958).
Thompson and Hecht, "Studies on a Long-Acting Vitamin B12 Preparation", Amer. J. Clin. Nutrition 7:311-317, (1959).
R. Nash, "The Pharamaceutical Suspension, Part 1", Drug & Cosmetic Industry, 97, (1965).
R. Nash, "The Pharmaceutical Suspension, Part 2", Drug & Cosmetic Industry, 98, (1966).
R. Nash, "Parenteral Suspensions", Bulletin of Parental Drug Assoc., 26:91-95, (1972).
M. Groves, "The Formulation of Parenteral Products", Parenteral Products, pp. 14-47, (1973).
Y. Chien, "Long-Acting Parenteral Drug Formulations", Jour. Parenteral Sci. & Tech. 35:106-139, (1981).
Y. Chien, Novel Drug Delivery Systems, pp. 210-247, (1982).
Y. Chien, "Syringeability of Nonaqueous Parenteral Formulations --Development and Evaluation of a Testing Apparatus", J. Parenteral Sci. and Technol. 35:281-284.
Warner, Aluminum Carboxylates in Encyclopedia of Chemical Technology, Kirk and Ottmer, (1978).
Lippe, et al., "Use of Growth Hormone Gel", Archives of Disease in Childhood 54:609-613, (1979).
Fara, "Recent Advances in Parenteral Drug Delivery Systems", J. Parenteral Sci. and Technol. 37:20-25, (1983).
Dixon, "Chemistry of Pituitary Hormones", pp. 1-15, 26-39 and 59-68 from The Hormones, Pincus, et al., eds, Academic Press, New York and London, (1964).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Prolonged release of biologically active somatotropin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prolonged release of biologically active somatotropin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prolonged release of biologically active somatotropin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-939688

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.