Process for the synthesis of vincamine and related indole alkalo

Details Process for the synthesis of vincamine and related indole alkalo Process for the synthesis of vincamine and related indole alkalo

1981-07-30

1983-04-12

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 70, C07D46100, C07D45500

Patent

active

043799353

ABSTRACT:
A process is taught for the synthesis of vincamine and related indole alkaloids, according to which, through only two steps and through a novel synthesis intermediate, namely the glycidic ester, having the formula ##STR1## wherein R" represents --COOCH.sub.3 or --COOCH.sub.2 CH.sub.3, 1-ethyl-1,2,3,4,5,6,7,12b-octahydroindole[2,3-a]quinolizine-1-carboxaldehy de is reacted with a haloester in the presence of a base and the glycidic ester is converted to vincamine or apovincamine or like esters by reaction with a Lewis acid or a mineral acid, the reaction products being subsequently separated by chromatography.

REFERENCES:
patent: 3755333 (1973-08-01), Szantay et al.
patent: 4033969 (1977-07-01), Sevenet et al.
patent: 4267330 (1981-05-01), Kuehne

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