Nucleoside modifications by palladium catalyzed methods

Details Nucleoside modifications by palladium catalyzed methods Nucleoside modifications by palladium catalyzed methods

1998-09-25

2000-02-01

Crane, L. Eric

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2714, 536 272, 536 273, 536 274, 536 275, 536 276, 536 2761, 536 2762, 536 2763, 536 277, 536 278, 536 2781, 536 282, 536 283, 536 284, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, C07H 1906

Patent

active

060204834

ABSTRACT:
This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.

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