Nucleic acids encoding CR1 fusion protein, vector, transfected c

Details Nucleic acids encoding CR1 fusion protein, vector, transfected c Nucleic acids encoding CR1 fusion protein, vector, transfected c

1995-06-05

2000-02-01

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 4353201, 4352523, 536 234, 536 235, 536 2431, C07H 2104, C07H 2102, C12P 2102

Patent

active

06020155&

ABSTRACT:
A method for producing a complementary DNA (cDNA) library enriched in ligand-inducible genes of a cell is described. The method includes activating a cellular ligand receptor for a predetermined period of time in the presence of labelled RNA precursors and a substance which enhances the level of RNA in the cell. The RNA precursors are incorporated into the RNA synthesized by the cell in response to receptor activation. The labelled RNA is separated from unlabelled RNA and used to prepare cDNA. The cDNA is cloned into host cells to provide a cDNA library of cDNA-containing clones, which is then screened for clones containing ligand-induced genes. Also described are several novel ligand-induced genes identified using the method of the invention.

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