N-substituted-4-pyrimidinamines and pyrimidinediamines

Details N-substituted-4-pyrimidinamines and pyrimidinediamines N-substituted-4-pyrimidinamines and pyrimidinediamines

1989-09-05

1991-01-08

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514269, 514272, 514274, 514275, 544319, 544326, 544328, 544323, 544324, 544325, 544310, 544311, 544312, 544317, 544320, 544321, C07D40312, C07D40314, A61K 31505

Patent

active

049836080

ABSTRACT:
This invention relates to N-heteroaryl-4-pyrimidinamines of the formula ##STR1## where R.sub.1 is hydrogen, loweralkyl, aryl, or arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen or loweralkyl, or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen or lowealkyl, or R.sub.4 and R.sub.5 taken together are aryl; X is hydrogen, halogen, cyano, nitro, amino, loweralkyl, loweralkoxy, trifluoromethyl or ##STR2## where Y is hydrogen, halogen or loweralkyl; m is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometrical and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as memory enhancing agents and as analgesic agents.

REFERENCES:
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patent: 4792562 (1988-12-01), Effland et al.
patent: 4806554 (1989-02-01), Effland et al.
patent: 4868190 (1989-09-01), Effland et al.
Petrow, J. Chem. Soc., 1945 927-928.
Wesseling et al., New England Journal of Medicine, 310 (15) 988-989 (1984).
Miller et al., J. Med. Chem. 13 (5), 1022-1023 (1970).

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