DNA sequence encoding modified hepatitis B virus surface antigen

Details DNA sequence encoding modified hepatitis B virus surface antigen DNA sequence encoding modified hepatitis B virus surface antigen

1986-08-20

1991-01-08

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435711, 435 91, 435170, 435171, 4351721, 4351723, 435235, 4352523, 435259, 435320, 435940, 536 27, 935 10, 935 22, 935 55, 935 60, 935 66, 424 88, C12N 113, C12N 119, C12N 700, C12N 1511, C12N 1534, C12N 1581, A61K 3900

Patent

active

049835203

ABSTRACT:
A modified protein (i) derived from a hepatitis B virus surface antigen P31 protein and (ii) having hepatitis B virus surface antigen activity and the ability to bind polymerized human serum albumin, wherein the modification comprises rendering at least one trypsin-like protease sensitive site of the hepatitis B virus surface antigen P31 protein insensitive. The modified protein can be used in the production of a vaccine for prevention of hepatitis B virus infections and as an antigen for diagnosis of hepatitis B virus infections.

REFERENCES:
patent: 4428941 (1984-01-01), Galibert et al.
patent: 4650674 (1987-03-01), Aggarwal et al.
Michel et al., 1984, PNAS 81:7708-7712.
Sanchez et al., 1981, Virology 114(1):71-80.
Nature, 298, 347-350 (1882).
#5--A Hepatitis-B Surface Antigen Polypeptide (P31) with the Receptor for Polymerized Human as Well as Chimpanzee Albumins, A. Machida et al.; Gastroenterology, Jul.-Dec. 1983, vol. 85, pp. 268-274.
#6--A Polypeptide Containing 55 Amino Acid Residues Coded by the Pre-S Region of Hepatitis-B Virus Deoxyribonucleic Acid Bears the Receptor for Polymerized Human as Well as Chimpanzee Albumins, A. Machida et al.; Gastroenterology, May 1984, vol. 81, No. 5, pp. 910-918.
#1--Synthesis and Assembly in Yeast of Hepatitis-B Surface Antigen Particles Containing the Polyalbumin Receptor, Pablo Valenzuela et al.; Bio/Technology, vol. 3, Apr. 1985, pp. 317-320.
Science, vol. 213, No. 4506, Tiollais et al., pp. 406-411.

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