Therapeutically active compound and its use

Details Therapeutically active compound and its use Therapeutically active compound and its use

1985-04-29

1992-06-23

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 64, 536 172, 536 173, 536 174, 536 175, 536 177, 536 176, 536 178, 536 179, 514192, 514193, 546294, 548165, 548166, C07H 1524, C07H 1702, C07J 1700, A01N 4304

Patent

active

051244411

ABSTRACT:
Therapeutically active organic compound exhibiting at least one group comprising a structure --S'--S"--R, wherein the group --S"--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S"--R obtainable by the splitting of the disulfide bridge --S'--S"-- in said structure, in which compound H--S"--R the sulfur atom S" is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H--S"--R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S" bound to R, so as to be mainly excluded from reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure --S'--S"--R, consisting of a residue of a therapeutically active organic base compound of non-polypeptide structure bound to S'.
The invention also relates to a method of modifying a therapeutically active organic compound of non-polypeptide structure by introducing a structure --S'--S"--R according to above; a method of treating diseases by administration of a compound according to the invention and also to a pharmaceutical composition containing at least one compound according to the invention.

Affiliated with

Also associated with

Rating

Therapeutically active compound and its use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutically active compound and its use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutically active compound and its use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-933952