Therapeutic agents of metabolic bone disease

Details Therapeutic agents of metabolic bone disease Therapeutic agents of metabolic bone disease

1990-06-08

1992-06-23

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142305, 514311, 514312, A61K 3154, A61K 3147

Patent

active

051243253

ABSTRACT:
New use of cyclic anthranilic acid derivatives of the following formula, ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each independently indicate a hydrogen atom, chlorine atom, lower alkyl group having 1 to 3 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, amino group, nitro group, hydroxy group, sulfonamide group, trifluoromethyl group, cyano group, carboxyl group, carbamoyl group, acetyl group, benzoymethyl group which may be substituted, methylthio group, phenylethnyl group which may be substituted, alkanoylamino group having 1 to 3 carbon atoms, benzoylamino group which may be substituted, alkylsulfonylamino group having 1 to 3 carbon atoms or phenylsulfonylamino group which may be substituted; R.sup.4 and R.sup.5 each independently indicate a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms, cyano group, carboxyl group, hydroxymethyl group, phenyl group which may be substituted or benzoyl group, R.sup.6 indicates a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms or benzyl group; X indicates a methylene group, oxygen atom, sulfur atom, sulfinyl group or sulfonyl group, their acid or alkali salts thereof as therapeutic agents for metabolic bone diseases is described.

REFERENCES:
patent: 4956372 (1990-09-01), Kojima et al.

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