Treatment of arthritis, including rheumatoid arthritis, with rad

Details Treatment of arthritis, including rheumatoid arthritis, with rad Treatment of arthritis, including rheumatoid arthritis, with rad

1985-06-07

1988-06-21

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

128 11, A61K 4300, A61N 510

Patent

active

047524642

ABSTRACT:
Treatment of rheumatoid arthritis by administering a radioactive compound to the inflamed synovium of the articular joint. The compound comprises an aggregate suspension having a radionuclide entrapped therein. The aggregate suspension is a ferric or aluminum hydroxide aggregate, and the radionuclide is selected from the group consisting of .sup.166 Holmium, .sup.153 Samarium, .sup.175 Ytterbium, .sup.169 Erbium, and .sup.176m Lutetium. The radionculide may also consist of .sup.51 Chromium. Suitable leakage inhibitors or agents to reduce leakage of the radionuclide from the articular joint is included as part of the chemical composition of the final drug form.

REFERENCES:
patent: 3961038 (1976-06-01), Benes
Hackh's Chemical Dictionary, 4th Edition, McGraw-Hill, p. 168 (1969).
Singh et al, Indian J. Radiology, 25(4), Nov. 1971.
Hnatowich et al, CA 88:148276, 1978.
Rebut-Bonneton et al, CA 84:161223, 1976.
Bertrand et al, CA 87:1863, 1977.
Bard et al, CA 99:136168, 1983.

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