Hyaluronics acid fractions, methods for the preparation thereof,

Details Hyaluronics acid fractions, methods for the preparation thereof, Hyaluronics acid fractions, methods for the preparation thereof,

1989-12-19

1992-11-24

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 54, 514420, 514576, 514777, 514912, 424 7805, C07H 504, C07H 506, A01N 4304, A61K 37715

Patent

active

051663317

ABSTRACT:
Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.
In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.

REFERENCES:
patent: 3870791 (1975-03-01), Haddad et al.
patent: 4141973 (1979-02-01), Balazs
patent: 4255415 (1981-03-01), Chrai et al.
Takashi et al, The Journal of Antibiotics vo. 31 (1978) pp. 150-155.
Cleland, Chemical Abstracts, vol. 76 (1972) No. 43075q "Molecular Weight Distribution in Hyaluronic Acid".
Laurent et al, Chemical Abstracts, vol. 98(1983) No. 211815f "The Molecular Weight of hyaluronate in the Aqueous Humor . . . ".
Shimada et al;, J. Biochem. vol. 31 (1977) pp. 79-91 "Molecular Weight of Hyaluronic Acid from Rabbit Skin".
Barron et al, American Journal of Ophthalmology vol 100 (1985) pp. 377-389 "Comparison of the Effects of Viscoat and Nealon".

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