Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1986-09-02
1988-01-12
Hollrah, Glennon H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C07C 8722
Patent
active
047193123
ABSTRACT:
The present invention is concerned with the preparation of lysosomotropic detergent agents and pharmaceutical composition useful in the treatment of cancer. These compounds are amine derivatives having a pK of 3.5 of the general structure ##STR1## in which R.sub.1 is C.sub.8-30 alkyl, C.sub.8-30 -alkenyl, substituted C.sub.4-30 alkyl or substituted C.sub.4-30 -alkenyl; R.sub.2 is hydrogen or C.sub.1-4 alkyl and Y is an electron withdrawing group, to control the pK, selected from trifluoroethyl, and difluoroethyl.
REFERENCES:
patent: 3077499 (1963-02-01), Tullock
patent: 3118945 (1964-01-01), Cohen
patent: 3214412 (1965-10-01), Brown
patent: 4059629 (1977-11-01), Foulletier et al.
"Lysosomotropic Agents. 1. Synthesis and Cytotoxic Action of Lysosomotropic Detergents", Journal of Medicinal Chemistry, vol. 22, No. 9, 1979, pp. 1130-1133.
Caruso Charles M.
Hollrah Glennon H.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Sopp John A.
LandOfFree
Lysosometropic detergent therapeutic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lysosometropic detergent therapeutic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lysosometropic detergent therapeutic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-921933