Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1985-08-19
1988-01-12
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424DIG7, 424453, 514962, 514963, A61K 948, A61K 307, C08J 930, C08L 8904
Patent
active
047191120
ABSTRACT:
Foam capsules with telescopically engaged body and cap portions, also known as hard shell capsules, having a special wall structure, obtained by a microdispersion of a gas in a gelatin solution.
The capsule body and cap portions are formed by dipmolding the film-forming mixture obtained by a microdispersion of the gas in a gelatin solution; optionally with the inclusion of a plasticizer and/or coloring agent, and/or flavoring agent, and/or foam stabilizer, and/or gelatin extender.
By a suitable choice of the gas proportion in the capsule wall and its micronization level, it is possible, within certain limits, to control the capsule wall disintegration speed and its opacity. In addition, inclusion of gas bubbles into the capsule wall lowers the gelatin content for a foam capsule and provides energy saving during the process due to a faster drying of the wall, thereby providing lower cost prices for the production of pharmaceutically acceptable capsules.
REFERENCES:
patent: 3173840 (1965-03-01), Hostetler et al.
patent: 3555132 (1971-01-01), Benning
patent: 3620759 (1971-11-01), Maddox
patent: 3823816 (1974-07-01), Controulis et al.
patent: 4086331 (1978-04-01), Neumann
patent: 4331547 (1982-05-01), Stotts et al.
patent: 4500358 (1985-02-01), Mayer et al.
patent: 4609403 (1986-09-01), Wittwer et al.
Mayer Jean P.
Wittwer Fritz
Griffin Ronald W.
Olevsky Howard
Raines Stephen
Warner-Lambert & Company
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