Treatment of sarcoma with interleukin 1.alpha. polypeptides

Details Treatment of sarcoma with interleukin 1.alpha. polypeptides Treatment of sarcoma with interleukin 1.alpha. polypeptides

Filed on

1992-09-30

Date issued

1994-12-27

Examiner

Draper, Garnette D.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Peptide containing doai

Other Related Categories

424 852, 530351, 930141, A61K 3702

Type

Patent

Status

active

Patent number

053766393

Description

ABSTRACT:
DNAs encoding polypeptides having interleukin 1, vectors inserted with said DNAs, hosts transformed with said recombinant vectors, polypeptides having interleukin 1 activity which are produced by cultivation of the transformed hosts, derivatives of the polypeptides, pharmaceutical composition containing said polypeptides or derivatives, their use as an antitumor or antiinfectious agent, and processes for the preparation thereof.

REFERENCES:
patent: 4816436 (1989-03-01), Jacobs
patent: 5039790 (1991-08-01), Adams et al.
patent: 5047505 (1991-09-01), Huang
patent: 5075288 (1991-12-01), Krueger et al.
Auron, et al. (1984) Lymphokine Research 3, 285.
Auron, et al. (1984) Proc. Natl. Acad. Sci. USA 81, 7907.
Furutani et al. (1985) Nucleic Acids Res. 13, 5869.
Krakauer (1985) Preparative Biochemistry 14, 449.
Kronheim, et al. (1985) Journal of Experimental Medicine 161, 490.
Lomedico, et al. (1984) Nature 312, 458.
March, et al. (1985) Nature 315, 641.
Mosley, et al. (1985) Progress in Leukocyte Biology 2, 521.
Scala, et al. (1984) Nature 309, 56.
Durum et al., Ann. Rev. Immunol 1985, 3, pp. 263-287.
Immunophysical: The Rate of Cells and Cytakines in Immunity and Inflammation, Opperheim et al., 1990, pp. 210-214.

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