Cancer therapy with interferon

Drug – bio-affecting and body treating compositions – Lymphokine

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530351, A61K 4502

Patent

active

047627050

ABSTRACT:
The effectiveness of interferon for treatment against cancer may be increased by first administering an agent for inhibiting tyrosinase. In this manner the tyrosinase which is known to be produced by malignancies, and which may cause inactivation of the interferon, will be substantially inactivated prior to the interferon administration.

REFERENCES:
Lerner, Article in Methods in Enzymology, vol. II, pp. 827-831 (1955).
Chemical Abstracts, vol. 84, Abstract No. 69303c, 1976.
Chemical Abstracts, vol. 91, Abstract No. 83177r, 1979.
Mazzara-Porro, M., et al., Pigment Cell, vol. 4, pp. 234-243, 1979.
Johnson, R, JAMA, vol. 245, No. 2, pp. 109-116, 1981.
Priestman, T. J., "Interferon: An Anti-Cancer Agent?" Cancer Treatment Reviews, 6, 223-237 (1979).
Sikora, K., "Does Interferon Cure Cancer?" British Medical Journal, 281, pp. 855-858 (1980).
Chen, Y. M. et al, "Serum Tyrosinase in Malignant Disease, Its Activity, and the Electrophoretic Patterns of the Enzyme as Carried by Immunoglobulins", Cancer Research, 39, pp. 3485-3490 (1979).
Sizer, I. W., "Oxidation of Proteins by Tyrosinase and Peroxidase", Advances in Enzymology, 14, 129-159, (1953).
Warren, S. L., "A Practitioner's Guide to Interferon", Annals of Allergy, 45, pp. 37-42, (1980).
Zoon, K. C. et al, "Amino Terminal Sequence of the Major Component of Human Lymphoblastoid Interferon", Science, 207, p. 527 (1980).
Knight, Jr., E. "Human Fibroblast Interferon: Amino Acid Analysis and Amino Terminal Amino Acid Sequence", Science, 207, pp. 525-526 (1980).
Houghton, M., et al, "The Complete Amino Acid Sequence of Human Fibroblast Interferon as Deduced Using Synthetic Oligodeoxyribonucleotide Primers of Reverse Transcriptase", Nucleic Acids Research, vol. 8, No. 13, 2885-93 (1980).
Nazzaro-Porro, M. et al, "Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum", The Journal of Investigative Dermatology, 71:205-208 (1978).
Breathnach, A. S., et al, "Effect of Dicarboxylic Acids on Normal Human Melanocytes in Dispersed Tissue Culture", British Journal of Dermatology, 101, pp. 641-649 (1979).
Nazzaro-Porro M. et al, "Effect of Azelaic Acid on Human Malignant Melanoma", The Lancet, May 24, 1980, pp. 1109-1111.
Dawson, C. R. et al, "Plant Tyrosinase (Polyphenol Oxidase)", Methods in Enzymology, 2, 817-827 (1955).
McCarty, M. F., Non-Toxic Inhibition of Extracellular Tumor Enzymes--Potential In Cancer Therapy, Medical Hypothesis, 8, 303-310, 1982.
Rubin, D. M., et al., "The Possible Role of Tyrosinase in Malignant Growth", Medical Hypothesis, 10:469-471 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cancer therapy with interferon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cancer therapy with interferon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cancer therapy with interferon will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-917938

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.