Method for the preparation of a therapeutically active compound

Details Method for the preparation of a therapeutically active compound Method for the preparation of a therapeutically active compound

1987-07-13

1989-09-12

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40104, C07D23948

Patent

active

048661740

ABSTRACT:
A method for the preparation of 2,4-diamino-3-oxy-6-piperidyl-pyrimidine or minoxidil wherein a compound of the formula ##STR1## wherein R is a C.sub.1-4 alkyl or a phenyl group optionally having up to three C.sub.1-4 alkyl substituents, is oxidized to a compound of the formula ##STR2## which according to known methods is reacted with piperidine to minoxidil. In the inventive method magnesium monoperoxyphthalate, which has the formula ##STR3## is used as the oxidizing agent.

REFERENCES:
patent: 3644364 (1972-02-01), Anthony
patent: 3998827 (1976-12-01), Thomas, Jr. et al.
patent: 4483781 (1984-11-01), Hartman
Chemical Abstracts, vol. 95, No. 23, Abstract 203,982f, 687, Dec. 7, 1981.

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