Dentifrice for dental remineralization

Details Dentifrice for dental remineralization Dentifrice for dental remineralization

1979-03-14

1979-12-04

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

Fluorine or fluorine compound containing

424 49, 424 54, 424 56, 424 57, A61K 718, A61K 722

Patent

active

041772580

ABSTRACT:
A dentifrice useful for remineralizing subsurface carious lesions of dental enamel which contains sources of calcium ions and phosphate ions as well as fluoride ions and further includes as agent to stabilize against precipitation of the calcium and phosphate ions, an antinucleating agent such as ethylenediamine tetramethylenephosphonic acid or water soluble salt thereof, the pH of the dentifrice being about 5-9, preferably close to physiological conditions, such as about 6.8-7.5.

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patent: 3625569 (1972-02-01), Medcalf
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patent: 3792152 (1974-02-01), Kim
patent: 3832396 (1974-08-01), Irani et al.
patent: 4097588 (1978-06-01), Levine
patent: 4110429 (1978-08-01), Gaffar et al.
Meyer and Nancollas, Calc. Tiss. Res. 13:245-303 (1973), The Influence of Multi-Dentate Phosphonates on the Crystal Growth of Hydroxyapatite.
Briner et al., Calc. Tiss. Res. 7:249-256 (1971), Factors Affecting the Rate of Post-Eruptive Maturation of Dental Enamel.
Monsanto Co. Brochure, "Dequest" Organophosphorus Compounds, Feb. 1971.

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