Cyclopropylpyrroloindole-oligopeptide anticancer agents

Details Cyclopropylpyrroloindole-oligopeptide anticancer agents Cyclopropylpyrroloindole-oligopeptide anticancer agents

1995-01-31

1996-03-26

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514370, 514377, 514406, 514410, 548181, 548233, 5482626, 5482654, 5483117, 5483647, 548421, A61K 3140, C07D48704

Patent

active

055020682

ABSTRACT:
The invention is directed to novel cyclopropylpyrroloindole-oligopeptide compounds which are useful as anticancer agents. The novel cyclopropylpyrroloindole-oligopeptide compounds have the following general structure: ##STR1## wherein, Het.sup.1 and Het.sup.2 are individually selected from the group consisting of pyrrole, imidazole, triazole, thiophene, furan, thiazole, oxazole and pyrazole,

REFERENCES:
patent: 4912199 (1990-03-01), Lown et al.
patent: 4978757 (1990-12-01), Kelly et al.
Wang et al., Journal of Medicinal Chemistry, "CC-1065 Functional Analogues Possessing Different Electron-Withdrawing Substituents and Leaving Groups: Synthesis Kinetics, and Sequence Specificity of Reaction with DNA and Biological Evaluation", pp. 4172-4182, vol. 36, No. 26 (1993).
Wang et al., Heterocycles, "An Alternative Method for Synthesis of the CC-1065 Pharmacophore, 1,2,7,7a-Tetrahydrocycloprop 1,2-c!Indol-4-One", pp. 1399-1410, vol. 36, No. 6, (1993).

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