Contrast agents for ultrasonic imaging

Surgery – Truss – Pad

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128661, 530427, A61B 1000

Patent

active

047184337

ABSTRACT:
A method of ultrasonic imaging for use in medical procedures is disclosed. The method comprises providing specifically defined microbubbles formed by sonicating a bicompatible liquid comprising a sonicated aqueous protein solution, preferably a 5% solution of human serum albumin, and denaturing the protein therein by heat or chemical methods; injecting the microbubbles into an animal or human to thereby alter the acoustic properties of an area to be imaged; and then ultrasonically scanning the area so as to obtain an ultrasound scanning image.

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Tickner, E. G. et al "Noninvasive Assessment of Pulmonary Hypertension Using the Buffle Ultrasonic Resonance Pressure (BURP) Method" National Technical Information SVC Dept #HR-62917-1A, Apr. 1977.
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Cate et al. (1984), JACC 3:21-27.
Ophir et al., "US Backscatter from Constant Producing Collagen Microspheres, US Imag 2 (1980), pp. 67-77.
Bommer et al., Abs., 53rd Scientific Sess., Nov. 17-20 (1980), American Heart Association Meeting.
Bommer et al., Abs., CIRC, Amer. J. Cardiology, vol. 47, 403 (1981).

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