N-terminus modified analogs of LHRH

Details N-terminus modified analogs of LHRH N-terminus modified analogs of LHRH

1994-07-27

1996-03-26

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530313, 530327, 530328, C07K 1459

Patent

active

055020356

ABSTRACT:
Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

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