Derivatives of aminopyridinecarboxylic acids and pharmaceutical

Details Derivatives of aminopyridinecarboxylic acids and pharmaceutical Derivatives of aminopyridinecarboxylic acids and pharmaceutical

1983-12-02

1985-07-09

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546297, 546309, 546291, 514352, C07D21380, C07D21379, C07D21375, A61K 31455

Patent

active

045282960

ABSTRACT:
Derivatives of aminopyridinecarboxylic acids which inhibit the dipeptidyl carboxy peptidase (DPCP), methods for their preparation and pharmaceutical compositions containing them.
The compounds have formula: ##STR1## where Z is hydrogen, alkyl having from 1 to 3 carbon atoms, halogen or alkoxy having from 1 to 3 carbon atoms;

REFERENCES:
patent: 3415835 (1968-12-01), Stempel
Merck Index, Tenth Edition, (1983), p. 244.
Wagner, G. et al., "Inhibitors of a Rat Brain Enkephalin Aminopeptidase", Journal of Neurochemistry, 37, (3), Sep. 1981, pp. 709-713.

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