Purinyl cyclobutanes

Details Purinyl cyclobutanes Purinyl cyclobutanes

1987-12-28

1989-08-08

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544244, 544265, 544277, 544264, 549215, C07D30300

Patent

active

048554669

ABSTRACT:
Disclosed are compounds having the formula ##STR1## wherein Prot is a hydroxyl protecting group. The compounds are useful as intermediates in the preparation of compounds of the formula ##STR2## which in turn are useful as antiviral agents.

REFERENCES:
patent: 4543255 (1985-09-01), Shealy et al.
Hoshino et al., Inhibition of Infectivity of Human Immunodifficiency Virus by Oxetanocin, J. Antibiotics, 40(7), 1077 (1987).
Shimada et al., Oxetanocin, A Novel Nucleoside From Bacteria, J. Antibiotics, 39(11), 1623 (1986).
Shealy et al., Synthesis and Antiviral Activity of Carbocyclic Analogues of 2'-Deoxyribofuranosides of 2-Amino-6-substituted-purines and of 2-Amino-6-substituted-8-azapurines, J. Med. Chem., 27, 1416 (1984).
Secrist et al., Resolution of Racemic Carbocyclic Analogues of Purine Nucleosides through the Action of Adenosine Deaminase, Antiviral Activity of the Carbocyclic 2'-Deoxyguanosine Enantiomers, J. Med. Chem., 30, 746 (1987).
Canning et al., Synthesis and Antiviral Activity of 9-[CIS]-2-[Hydroxymethyl)-Cyclopropmethyl] Guanine and Related Compounds, ACS National Meeting, 1986 (Abstract No. 33).
Nakamura, et al., The X-Ray Structure Determination of Oxetanocin, J. Antibiotics, 39, 1626-1629 (1986).
Niitsuma, et al., Studies on the Total Synthesis of Oxetanocin; I. The First Synthesis of a Nucleoside Having Oxetanosyl-N-Glycoside, Tetrahedron Letters, 28, 3967-3970 (1987).
Niitsuma, et al., Studies on the Total Synthesis of Oxetanocin; II. Total Synthesis of Oxetanocin; Tetrahedron Letters, 28, 4713-4714 (1987).
Austin, et al., Chiral Oxetanes From Sugar Lactones: Synthesis of Derivatives of 3,5-Anhydro-1,2-O-Isopropylidene- -D-Glucuronic Acid and of 3,5-Anhydro-1,2-O-Isopropylidene-B-L-Iduronic Acid, Tetrahedron Letters, 28, 4741-4744 (1987).
Shimada et al., Derivatives of Oxetanocin: Oxetanocins H, X and G, and 2-Aminooxetanocin A, J. Antibiotics, 40, 1788-1790 (1987).
Derwent Abstract No. 87-296034/42 of Japanese Specification JP-048499 published Sep. 12, 1987.

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