Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1987-04-13

1989-08-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540215, 540225, C07D50118, A61K 31545

Patent

active

048554200

ABSTRACT:
A cephalosporin derivative of the formula I: ##STR1## in which X is S, O, CH.sub.2 or SO, R1 is (optionally-substituted) imidazol-2-yl or one of the C-7 acyl groups known in the cephalosporin art, R2 is hydrogen or methoxy, R3 is carboxy or a biodegradable ester thereof and -R4 is of the formula XII, XIII or XIV: ##STR2## in which R32-R40 inclusive are as defined in the specification; and the salts thereof. Pharmaceutical compositions, methods of manufacture and intermediates are also described.

REFERENCES:
patent: 4386089 (1983-05-01), Konig
patent: 4463173 (1984-07-01), Jung
patent: 4492692 (1985-01-01), Jung et al.
patent: 4560749 (1985-12-01), Spry
patent: 4678781 (1987-07-01), Jung
J. Med. Chem., 1974, 17, 1312-1315 (Nomura et al.).

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