Immunoassays employing labeled reagent and a conjugate having tw

Details Immunoassays employing labeled reagent and a conjugate having tw Immunoassays employing labeled reagent and a conjugate having tw

1981-02-02

1983-08-30

Fagelson, Anna P.

Chemistry: analytical and immunological testing

Thyroid hormone tests

424 71, 436531, 436532, 436533, 436534, 436546, 436547, 436805, 436815, 436819, 436828, G01N 3348, G01N 3352, G01N 3354, G01N 3378

Patent

active

044017642

ABSTRACT:
In the immunoassay of antigens in liquids, a reaction mixture is formed containing the liquid under assay, labelled antigen, and a mixed binding reagent which contains an antigen-binding site and a label-binding site, the two sites being spaced apart in the reagent so that a single molecule of labelled antigen cannot bind to both sites. The label is one whose activity is changed upon binding to a label-binding site, and the amount of antigen in the original liquid sample is determined by measuring the activity of the label in the reaction mixture. A preferred label is a fluorophore. The mixed binding reagent preferably consists of two antibodies linked together.

REFERENCES:
patent: 3996345 (1976-12-01), Ullman
patent: 4108976 (1978-08-01), Reese
patent: 4161515 (1979-07-01), Ullman
Nargessi et al., J. Immunol. Methods, vol. 26, 1979, pp. 307-313.

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