Certain azaspirodecane compounds and a method of inducing an anx

Details Certain azaspirodecane compounds and a method of inducing an anx Certain azaspirodecane compounds and a method of inducing an anx

1987-12-10

1989-08-08

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 16, C07D22120, A61K 3145, A61K 31445

Patent

active

048553026

ABSTRACT:
A compound selected from the group consisting of azaspirodecane derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, alkoxy of 1 to 3 carbon atoms, --NO.sub.2, --NH.sub.2 and CH.sub.3 S-- in the 4,5 or 6 position of the ring, R' is oxo or hydrogen or --OH or alkyl of 1 to 3 carbon atoms and the dotted line indicates a carbon-carbon bond in the 2,3-position, n is 2,3,4 or 5 and the dotted line in the piperidyl ring is an optional carbon-carbon bond and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anxiolytic activity.

REFERENCES:
patent: 3635991 (1972-01-01), Archer

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