Non-addictive narcotic antitussive preparation

Details Non-addictive narcotic antitussive preparation Non-addictive narcotic antitussive preparation

1981-10-13

1983-08-30

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31485

Patent

active

044016727

ABSTRACT:
Non-addictive narcotic antitussive preparations including a normally addictive narcotic analgesic cough suppressive agent and a highly selective long-acting narcotic antagonist in a pharmaceutically acceptable liquid carrier. The narcotic antagonist is an opioid receptor site-directed alkylating agent. Preparations are disclosed having the effectiveness of codeine and other opiates for cough suppression, but devoid of addictive abuse potential.

REFERENCES:
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patent: 4241066 (1980-12-01), Kobylecki et al.
patent: 4241067 (1980-12-01), Kobylecki et al.
Jiang et al., J. Med. Chem., 20(8), pp. 1100-1102 (1977).
Portoghese et al. (I), J. Med. Chem., 21, pp. 598-599 (1978).
Portoghese et al. (II), J. Med. Chem., 22(2), pp. 168-173 (1979).
Portoghese et al. (III), J. Med. Chem., 23(3), pp. 233-234 (3/80).
Caruso et al., Science, 204, pp. 316-318 (4/20/79).

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