Human epidermal growth factor having substitution at position 11

Details Human epidermal growth factor having substitution at position 11 Human epidermal growth factor having substitution at position 11

1989-05-12

1992-10-27

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530399, 530350, A61K 3736, C07K 1300

Patent

active

051589354

ABSTRACT:
We have now found that one may improve the storage life of EGF without diminishing its biological activity by replacing the Asp at position 11 with a different amino acid, preferably Glu, Asn, Gln, Ala, or Lys, more preferably Glu, or Asn, and most preferably Glu. Other modifications may additionally be made, most preferably by substituting Met.sub.21 (which we have found is susceptible to oxidation) with Ile or a similar amino acid.

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