Methods and compositions for screening carcinomas

Details Methods and compositions for screening carcinomas Methods and compositions for screening carcinomas

1990-04-17

1992-10-27

Saunders, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 723, 435960, 436 63, 436 64, 436548, 436813, 530808, 53038885, 5303882, 935110, C07K 1528, G01N 33574, G01N 33577

Patent

active

051588935

ABSTRACT:
Methods for determining the prognosis of human carcinomas utilizing a marker specific for malignant cells of aggressive cancers. Cell lines have been produced that secrete monoclonal antibodies useful in detecting such markers, including a 51,000-dalton keratin protein, specific for myoepithelial cells, e.g., in tissue culture. Pharmaceutical compositions containing these antibodies, which can be in combination with cytotoxic agents and the use of such compositions in the management of carcinomas are included.
Prior to filing of this patent application, the continuous transformed cell lines described herein was deposited in the American Type Culture Collection and designated Accession No. HB9288.

REFERENCES:
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4599304 (1986-07-01), Lanier et al.
patent: 4612282 (1986-09-01), Schlom et al.
Barry A. Gusterson, et al., "Identification of Myoepithelial Cells in Human and Rat Breasts by Anti-Common Acute Lymphoblastic Leukemia Antigen Antibody A12," JNCI, Aug. 1986.
Peter J. Dempsey, et al., "A Monoclonal Antibody CIBr17 Recognizes a Myoepithelium-Specific Antigen in Human Mammary Gland," Int. J. Cancer, 1986.
Monoclonal antikeratin antibody: production, characterization, and immunohistochemical application, Eto et al., Chem Abst 102:202277f (1985).

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